| Annotated protein: | Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) (C1qTNF10) (CTRP10). Gene symbol: C1QL2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8CFR0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ C1QL2 |
| Ontology domain: | Biological Process |
| SynGO term: | neurotransmitter receptor localization to postsynaptic specialization membrane (GO:0099645) |
| Synapse type(s): | Mossy fiber synapse (DG->CA3) |
| Annotated paper: | Matsuda K, et al. "Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins" Neuron. 2016 May 18;90(4):752-67 PMID:27133466 |
| Figure(s): | Fig. 3, 5, 6, 7 |
| Annotation description: | C1ql2 and C1ql3 Determine Postsynaptic KAR Localization at MF-CA3 Synapses (Fig. 3) via signaling through Nrx3 -> C1ql2/3 -> Kainate receptor (Fig. 5). |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 3044 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |