Annotated protein:Complement C1q-like protein 2 (C1q and tumor necrosis factor-related protein 10) (C1q/TNF-related protein 10) (C1qTNF10) (CTRP10). Gene symbol: C1QL2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8CFR0
antibody wiki:
SynGO gene info:SynGO data @ C1QL2
Ontology domain:Cellular Component
SynGO term:synaptic cleft (GO:0043083)
Synapse type(s):Mossy fiber synapse (DG->CA3)
Annotated paper:Matsuda K, et al. "Transsynaptic Modulation of Kainate Receptor Functions by C1q-like Proteins" Neuron. 2016 May 18;90(4):752-67 PMID:27133466
Figure(s):Fig. 1C,D
Annotation description:In Fig. 1C postembedding immunogold EM localizes endogenous C1ql2 in WT MF-CA3 synapses to the synaptic cleft and the presynaptic membrane. In Fig 1D Super-resolution structured illumination (SIM) microscopy is used to localize C1ql2 between presynaptic Bassoon and postsynaptic PSD-95 immunoreactivities.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Super resolution
Annotator(s):Daniela Dieterich (ORCID:0000-0002-9880-1214)
Rainer Pielot (ORCID:0000-0002-9681-3318)
Karl-Heinz Smalla (ORCID:0000-0002-0269-0311)
Eckart Gundelfinger (ORCID:0000-0001-9377-7414)
Lab:Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany
SynGO annotation ID:3042
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology