| Annotated protein: | Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2). Gene symbol: KCNAB2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P62483 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KCNAB2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Proepper C, et al. "The Kvbeta2 subunit of voltage-gated potassium channels is interacting with ProSAP2/Shank3 in the PSD" Neuroscience. 2014 Mar 7;261:133-43 PMID:24211303 |
| Figure(s): | Fig.1, 2, 3 |
| Annotation description: | Fig.1: "Expression pattern of Kcnab2 transcripts encoding for the Kvβ2 protein in the developing CNS" - "On ultrastructural level Kvβ2 is located at postsynaptic sites in the PSD, visualized by pre-embedded immuno-electron microscopy (Fig. 1G). In subfractions of rat brain protein lysate Kvβ2 is present in all fractions except mitochondria and is enriched in the postsynaptic density. " Fig.2: "ProSAP2/Shank3 interacts with Kvβ2 via its PDZ/PRR domain" Fig.3: "Kvβ2 is interacting with the PDZ/PRR motifs of ProSAP2/Shank3 and is recruited into the clusters of ProSAP2/Shank3" 28/3/2018 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal IP + WB/MSMS Y2H |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3037 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |