| Annotated protein: | Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A). Gene symbol: ITPKA. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P17105 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ITPKA |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic actin cytoskeleton (GO:0098871) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Kim IH, et al. "Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling" J Neurosci. 2009 Nov 4;29(44):14039-49 PMID:19890013 |
| Figure(s): | Fig.1, 7 |
| Annotation description: | Fig.1: "IP3K-A accumulates in dendritic spines upon LTP induction" Fig.6: "IP3K-A recruits activated Rac1 onto F-actin fibers" - "Furthermore, p-PAK-IRs were dramatically merged with overexpressed GFP-IP3K-A signals, which are localized on the F-actin in the head of dendritic protrusions (Figure 3A and Figure 6C), suggesting that IP3K-A-dependent targeting of activated Rac onto F-actin cytoskeleton also occurs in neurons." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3036 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |