| Annotated protein: | Huntingtin interacting protein 1 related. Gene symbol: HIP1R. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q99PW9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HIP1R |
| Ontology domain: | Biological Process |
| SynGO term: | postsynapse organization (GO:0099173) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Peng L, et al. "Huntingtin-Interacting Protein 1-Related Protein Plays a Critical Role in Dendritic Development and Excitatory Synapse Formation in Hippocampal Neurons" Front Mol Neurosci. 2017 Jun 15;10:186 PMID:28663723 |
| Figure(s): | Fig.2, 3, 4, 6, 7 |
| Annotation description: | Fig.2: "Knockdown of HIP1R expression suppresses dendrite growth and spine formation" Fig.3: "Over-expression of HIP1R enhances dendritic growth and spine formation" Fig.4: "HIP1R knockdown decreases dynamics and density of dendritic filopodia" Fig.6: "Amplitude and frequency of miniature excitatory post-synaptic current (mEPSC), but not miniature inhibitory post-synaptic current (mIPSC), are reduced in HIP1R-knockeddown neurons" Fig.7: "Transfection of mouse HIP1R rescues the dendrite growth defects in HIP1R-knockeddown neurons. (A) A schematic illustration showing mouse full-length and several truncated forms of HIP1R cDNA in the myc-tagged expressing vector" Note: the effect of Huntingtin-interacting protein-1-related protein; HIP1R on postsynapse organization may be a downstream consequence of the role of this protein in clathrin-mediated endocytosis or actin dynamics. This is however not shown at that detail in the experiments in this paper nor in other publications at the moment of this writing. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3034 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |