| Annotated protein: | cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11). Gene symbol: PRKACA. Taxonomy: Mus musculus (Mouse). Uniprot ID: P05132 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PRKACA |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic modulation of chemical synaptic transmission (GO:0099170) |
| Synapse type(s): | retina, glutamatergic |
| Annotated paper: | Townsend M, et al. "Retina-driven dephosphorylation of the NR2A subunit correlates with faster NMDA receptor kinetics at developing retinocollicular synapses" J Neurosci. 2004 Dec 8;24(49):11098-107 PMID:15590926 |
| Figure(s): | Fig.2 |
| Annotation description: | Fig.2: "PKA lengthens the spontaneous NMDAR current decay time in opposition to CaN" - "Figure 2B (top two traces) shows the average NMDAR current from a single neuron in which the PKA-inhibitory peptide was introduced into the recording pipette solution (Wang et al., 1994b). After break-in, the cell was dialyzed for 20 min, and the decay times of spontaneous NMDAR currents were recorded. NMDAR current kinetics was fast, which is typical of other P11 neurons. However, when FK506 was added to the perfusion media, the PKA-inhibitory peptide prevented the lengthening of the NMDAR current decay time that normally occurred with CaN antagonists." Note: the authors show that PRKACA mediates the NMDA current decay time. Because the data do not show whether the intrinsic channel properties or NTR trafficking are affected I used the less specific term 'postsynaptic modulation of chemical synaptic transmission (GO:0099170)'. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3030 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |