| Annotated protein: | Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2). Gene symbol: KCNN2. Taxonomy: Mus musculus (Mouse). Uniprot ID: P58390 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KCNN2 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | cerebellum, glutamatergic |
| Annotated paper: | Ballesteros-Merino C, et al. "Localization of SK2 channels relative to excitatory synaptic sites in the mouse developing Purkinje cells" Front Neuroanat. 2014 Dec 15;8:154 PMID:25565979 |
| Figure(s): | Fig.4 |
| Annotation description: | Fig.4: "Electron micrographs of the cerebellar cortex showing immunoreactivity for SK2 during postnatal development as detected using a pre-embedding immunogold method." - "At P21, the highest density of SK2 immunoparticles was detected along the extrasynaptic plasma membrane of PC dendritic spines, followed by dendritic shafts (Figures 4K-L; Table Table1).1). At the presynaptic level, immunolabelling for SK2 was identifiable in PF synapses and their terminals (Figures 4M-N; Table Table1).1)." 27/3/2018 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3025 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |