| Annotated protein: | Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (Voltage-gated potassium channel subunit Kv2.1). Gene symbol: KCNB1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P15387 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KCNB1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic specialization membrane (GO:0099060) |
| Synapse type(s): | spinal cord, acetylcholinergic |
| Annotated paper: | Muennich EA, et al. "Focal aggregation of voltage-gated, Kv2.1 subunit-containing, potassium channels at synaptic sites in rat spinal motoneurones" J Physiol. 2004 Feb 1;554(Pt 3):673-85 PMID:14608003 |
| Figure(s): | Fig.5 |
| Annotation description: | Fig.5: "Kv2.1-IR is restricted to the postsynaptic membrane and is clustered at specific synaptic sites on the membrane" - "Most importantly, the labelling was always concentrated at the postsynaptic side of the synaptic apposition, with very little migration of reaction product into the synaptic cleft (Fig. 5). The immunolabelling is concentrated close to the surface membrane, and appears closely associated with the subsynaptic cistern (Fig. 5A, B and C). " |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3023 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |