| Annotated protein: | Cysteine-rich PDZ-binding protein (Cysteine-rich interactor of PDZ three) (Cysteine-rich interactor of PDZ3). Gene symbol: CRIPT. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q792Q4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CRIPT |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic density assembly (GO:0099151) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Passafaro M, et al. "Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95" Nat Neurosci. 1999 Dec;2(12):1063-9 PMID:10570482 |
| Figure(s): | Fig.4, 5 |
| Annotation description: | Figure 4: Inhibition of synaptic clustering of PSD-95 but not of NMDA receptors by Antp-CRIPT. Figure 5: Quantitation of Antp-CRIPT effects on PSD-95, chapsyn-110, GKAP, CRIPT and NMDA receptor clustering. - "In contrast to its severe inhibition of the clustering of PSD-95, chapsyn-110 and GKAP, Antp-CRIPT had no significant effect on the pattern or density of synaptophysin clusters in cultured hippocampal neurons (Figs. 4a and 5a and b). " 27/3/2018 Pim - CRIPT may be a 'structural constituent of the PSD' but until now I think there is too little data to support this claim. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3022 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |