| Annotated protein: | Cysteine-rich PDZ-binding protein (Cysteine-rich interactor of PDZ three) (Cysteine-rich interactor of PDZ3). Gene symbol: CRIPT. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q792Q4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CRIPT |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density, intracellular component (GO:0099092) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Valtschanoff JG, et al. "Laminar organization of the NMDA receptor complex within the postsynaptic density" J Neurosci. 2001 Feb 15;21(4):1211-7 PMID:11160391 |
| Figure(s): | Fig.2, 3 |
| Annotation description: | Fig.2: "Postembedding immunogold labeling for the proteins studied here" - "Gold particles coding for seven different proteins contributing to the biochemically defined NMDA receptor complex accumulated mainly over the PSD (Fig. 2)." Fig.3: "Graph shows "lateral" position of gold particles" - "Results of this procedure are given in Table3. These data reveal a laminar organization of proteins within the PSD; some (PSD-95 and NR2) lay close to the plasma membrane, others (CRIPT, GKAP, Shank, and DLC) lay markedly farther away" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Additional EM data. @ PMID:9581762 |
| SynGO annotation ID: | 3021 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |