| Annotated protein: | Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (CPEB) (CPEB-1). Gene symbol: CPEB1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P0C279 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CPEB1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Wu L, et al. "CPEB-mediated cytoplasmic polyadenylation and the regulation of experience-dependent translation of alpha-CaMKII mRNA at synapses" Neuron. 1998 Nov;21(5):1129-39 PMID:9856468 |
| Figure(s): | Fig.3 |
| Annotation description: | Fig.3: "CPEB Localizes to Synapses in Hippocampal Neurons In Vitro" - "CPEB immunoreactivity displays a similar distribution to that of synapses on this neuron. A higher magnification of a dendrite taken from two different neurons demonstrates CPEB colocalization with synapses (arrows). Some synapses have little or no CPEB colocalization (small arrowheads)." - "CPEB is enriched in the postsynaptic density" |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3016 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |