| Annotated protein: | Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (mCPEB) (mCPEB-1). Gene symbol: CPEB1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P70166 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CPEB1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of translation at synapse, modulating synaptic transmission (GO:0099547) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Zearfoss NR, et al. "A molecular circuit composed of CPEB-1 and c-Jun controls growth hormone-mediated synaptic plasticity in the mouse hippocampus" J Neurosci. 2008 Aug 20;28(34):8502-9 PMID:18716208 |
| Figure(s): | Fig.3, 4 |
| Annotation description: | Fig.3: "CPEB-1 regulates c-Jun RNA translation" Fig.4: "Analysis of GH-induced LTP" - " Bath application of recombinant human GH (22 ng/ml) onto slices elicits LTP in wild-type and CPEB-1 KO mice. Note that, at 90-120 min, the amplitude of the LTP in KO animals is 55% of that in the wild-type animals (n = 5 each for wild type and KO)." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings ChIP |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Effect on LTP are also shown in this paper. @ PMID:15169862 |
| SynGO annotation ID: | 3015 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |