| Annotated protein: | Calponin-3 (Calponin, acidic isoform) (Calponin, non-muscle isoform). Gene symbol: CNN3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P37397 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CNN3 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Agassandian C, et al. "Subcellular distribution of calponin and caldesmon in rat hippocampus" Brain Res. 2000 Dec 29;887(2):444-9 PMID:11134639 |
| Figure(s): | Fig.2 |
| Annotation description: | Fig.2: "Calponin and caldesmon immunoreactivity are postsynaptic." - "(a-c) Calponin-immunolabelling is particularly enriched in dendritic spines (Sp) where it is localised between the sacks of the spine apparatus (large arrow), and in the plasma membrane of neurones such as the cell cortex (small arrows) and the post-synaptic density (white arrow). Acidic Cp-immunoreactivity is present as scattered deposits in the subsynaptic web of both asymmetric (b) and symmetric (c) synapses suggesting that the function of this protein is not dependent on the type of synapses." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 3010 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |