| Annotated protein: | Ephrin type-A receptor 4 (EC 2.7.10.1) (Tyrosine-protein kinase receptor MPK-3) (Tyrosine-protein kinase receptor SEK-1). Gene symbol: EPHA4. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q03137 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ EPHA4 |
| Ontology domain: | Biological Process |
| SynGO term: | synapse disassembly (GO:0098883) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Murai KK, et al. "Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling" Nat Neurosci. 2003 Feb;6(2):153-60 PMID:12496762 |
| Figure(s): | Figs. 2, 4, 6 |
| Annotation description: | Known ligands (ephrin-A1, ephrin-A3 and ephrin-B2) for EphA4 induce its phosphorylation. Adding a dimerized Fc fusion of the extracellular domain of ephrin-A3 caused spine length retraction, whereas EphA4 Fc moderately reduced spine width presumably due to a dominant-negative effect on endogenous EphA4 interactions (Fig. 2). Dendritic spines of CA1 pyramidal neurons are longer in P19-P21 EphA4 knockout mice, while spine density is normal (Fig. 4). Cells transfected with kinase-inactive EphA4 have longer spines in pyramidal neurons in slices (Fig. 6). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression Antagonist / agonist Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 301 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |