| Annotated protein: | Drebrin-like protein (Actin-binding protein 1) (Abp1) (SH3 domain-containing protein 7). Gene symbol: DBNL. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9JHL4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DBNL |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Yamazaki H, et al. "Molecular cloning and dendritic localization of rat SH3P7" Eur J Neurosci. 2001 Sep;14(6):998-1008 PMID:11595038 |
| Figure(s): | Fig.9 |
| Annotation description: | Fig.9: "Immunogold EM localization of SH3P7 in the stratum radiatum in the CA1 region of the hippocampus" - " Immunogold labelling for SH3P7 in the stratum radiatum within the CA1 region of the hippocampus was located predominantly in the postsynaptic site (Fig.9A). In contrast, presynaptic terminals were almost devoid of SH3P7-IR. As expected, synaptophysin-positive gold particles were observed at the presynaptic site (Fig.9C)." Note: the image is quite difficult to decipher. There are independent reports of pre- and postsynaptic localization in other less resolution papers (see additional literature). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Shows interaction and co-localization with postsynaptic scaffold proteins. @ PMID:15014124 Shows interaction and co-localization with presynaptic scaffold protein piccolo. Literal: "The subcellular localization of Abp1 is not restricted to dendrites and cell bodies but also includes the axonal compartment" @ PMID:12654920 |
| SynGO annotation ID: | 3005 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |