Annotated protein:Disks large homolog 5. Gene symbol: DLG5. Taxonomy: Mus musculus (Mouse). Uniprot ID: E9Q9R9
antibody wiki:
SynGO gene info:SynGO data @ DLG5
Ontology domain:Biological Process
SynGO term:postsynapse organization (GO:0099173)
Synapse type(s):neocortex, glutamatergic
Annotated paper:Wang SH, et al. "Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization" J Neurosci. 2014 Sep 17;34(38):12745-61 PMID:25232112
Figure(s):Fig.4, 5
Annotation description:Fig.4: "DLG5 regulates dendritic spine density in layer V cortical pyramidal neurons in vivo"
- "Dlg5LP/LP layer V pyramidal neurons exhibit a 38% and 44% reduction in dendritic spine density along oblique branches of primary apical dendrites and basal dendrites, respectively (Fig. 4A-C)."

Fig.5: "DLG5 regulates dendritic spine density cell autonomously"
- " At P21, layer V cortical neurons electroporated with Dlg5 shRNA show a 25% reduction in dendritic spine density compared with neurons electroporated with the GFP control (Fig. 5M-O)."

Note: Dlg5 seems to influence spine formation via directing localization of β-catenin and N-cadherin: "On a molecular level, DLG5 regulates synaptogenesis by controlling the subcellular localization of β-catenin and N-cadherin"
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Genetic transformation (eg; knockout, knockin, mutations)
Evidence tracking, Experiment Assay:Confocal
Microscopy (generic)
Annotator(s):Pim van Nierop (ORCID:0000-0003-0593-3443)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:3000
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology