| Annotated protein: | Syntaxin-4. Gene symbol: STX4. Taxonomy: Mus musculus (Mouse). Uniprot ID: P70452 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ STX4 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Mori Y, et al. "Small GTPase Rab17 regulates the surface expression of kainate receptors but not alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in hippocampal neurons via dendritic trafficking of Syntaxin-4 protein" J Biol Chem. 2014 Jul 25;289(30):20773-87 PMID:24895134 |
| Figure(s): | Fig.4 |
| Annotation description: | Fig.4: "Rab17 co-localizes with Syntaxin-4 in the dendritic shaft, tip, and spine" Note: Rab17 is in this paper shown to transport Stx4 from the cell soma to the dendrites thereby influencing KAR membrane levels. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2998 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |