| Annotated protein: | Dedicator of cytokinesis protein 10 (Zizimin-3). Gene symbol: DOCK10. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BZN6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DOCK10 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Jaudon F, et al. "The RhoGEF DOCK10 is essential for dendritic spine morphogenesis" Mol Biol Cell. 2015 Jun 1;26(11):2112-27 PMID:25851601 |
| Figure(s): | Fig.4 |
| Annotation description: | Fig.4: "DOCK10 is expressed in the hippocampus and localized in dendritic spines in hippocampal neurons" - "This showed that DOCK10 was present in the synaptosomal fraction, where it fractionated together with the postsynaptic density protein PSD-95 (Figure 4B), indicating a synaptic localization for DOCK10." - "Figure 4D shows that DOCK10 was localized in the dendritic shaft and most strikingly in the dendritic spines in hippocampal neurons, which is compatible with a function of DOCK10 in dendritic spine morphogenesis. In addition, DOCK10 immunostaining in the spines localized adjacent to the presynaptic protein Bassoon (Figure 4E)." |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2995 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |