| Annotated protein: | Disks large homolog 5. Gene symbol: DLG5. Taxonomy: Mus musculus (Mouse). Uniprot ID: E9Q9R9 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DLG5 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | brain, glutamatergic |
| Annotated paper: | Wang SH, et al. "Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization" J Neurosci. 2014 Sep 17;34(38):12745-61 PMID:25232112 |
| Figure(s): | Fig.3 |
| Annotation description: | Fig.3: "Dlg5 Is expressed in the postnatal brain and enriched in postsynaptic density fractions" - " DLG5 is highly enriched in PSD fractions in wild-type brains and the mutant DLG5LP protein, though present at lower levels than wild-type, retains its localization in the PSD fraction (Fig. 3G). These results show that DLG5 is a PSD component and that it is included in the PSD core protein-containing detergent-insoluble PSDIII fraction." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2994 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |