| Annotated protein: | Disrupted in schizophrenia 1 protein. Gene symbol: DISC1. Taxonomy: Homo sapiens (Human). Uniprot ID: Q9NRI5 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DISC1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | neocortex, glutamatergic |
| Annotated paper: | Kirkpatrick B, et al. "DISC1 immunoreactivity at the light and ultrastructural level in the human neocortex" J Comp Neurol. 2006 Jul 20;497(3):436-50 PMID:16736468 |
| Figure(s): | Fig.6 |
| Annotation description: | Fig.6: "Electron micrograph of DISC1 immunoreactivity in the neuropil in Brodmann Area 9" - "The mostcommon configuration was an unlabeled AT forming anasymmetric synapse with a spine that had immunoreac-tivity deposited on the PSD and throughout the spine." - "Labeled ATs formed synapses with labeled spines and dendrites; insome of these, only the PSD of the postsynaptic structurewas labeled. Immunolabeled ATs formed asymmetric andsymmetric synapses with equal frequency" Note: AT means axon terminal (presynapse). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2991 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |