| Annotated protein: | Dapper homolog 1 (Dapper antagonist of catenin 1) (Frodo homolog) (MDpr1) (Thymus-expressed novel gene 3 protein). Gene symbol: DACT1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8R4A3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DACT1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse organization (GO:0099175) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Okerlund ND, et al. "Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain" J Neurosci. 2010 Mar 24;30(12):4362-8 PMID:20335472 |
| Figure(s): | Fig.2, 3 |
| Annotation description: | Fig.2: "Dact1 mutant neurons have simpler dendritic arbors, fewer spines, and more filopodia; phenotypes rescued by recombinant Dact1" Fig.3: "Dact1 mutant neurons have fewer excitatory synapses; inhibitory synapses are spared" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2988 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |