| Annotated protein: | Voltage-dependent anion-selective channel protein 1 (VDAC-1) (rVDAC1) (Outer mitochondrial membrane protein porin 1). Gene symbol: VDAC1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9Z2L0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ VDAC1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Annotated paper: | Moon JI, et al. "Presence of a voltage-dependent anion channel 1 in the rat postsynaptic density fraction" Neuroreport. 1999 Feb 25;10(3):443-7 PMID:10208569 |
| Figure(s): | fig 2b, 3 |
| Annotation description: | From Results section: "the immunoblot signal for VDAC1 was stronger in the PSD lane than in brain homogenate and synaptosome lanes (Fig. 2B, arrowhead), indicating that VDAC1 is enriched in the PSD fraction." "the immunoblot signal for VDAC1 was stronger in the PSD lane than in brain homogenate and synaptosome lanes (Fig. 2B, arrowhead), indicating that VDAC1 is enriched in the PSD fraction." 27/3/2018 Pim - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) |
| Annotator(s): | Rita Reig-Viader (ORCID:0000-0002-6893-6177) Àlex Bayés (ORCID:0000-0002-5265-6306) |
| Lab: | Molecular Physiology of the Synapse Laboratory, Biomedical Research Institute Sant Pau, 08025 Barcelona, Spain and and Universitat Autnoma de Cerdanyola del Valls, Spain Barcelona, 08193 Bellaterra |
| SynGO annotation ID: | 2984 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |