| Annotated protein: | Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5). Gene symbol: ARHGEF15. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q5FWH6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ARHGEF15 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Hamilton AM, et al. "A dual role for the RhoGEF Ephexin5 in regulation of dendritic spine outgrowth" Mol Cell Neurosci. 2017 Apr;80:66-74 PMID:28185854 |
| Figure(s): | Fig.2, 3 |
| Annotation description: | Fig.2: "Dendritic Ephexin5 levels are reduced in response to increased neural activity" - "After 2-3 days of expression, we found that E5-GFP was present in the dendrite and concentrated in dendritic spines (Fig. 2A). T" Fig.3: "Ephexin5-GFP is enriched at sites of new spine outgrowth" - "Remarkably, we also found that E5-GFP was enriched on the dendrite at sites of new spine outgrowth, even 20 min before the appearance of the new spine (G/R 0.044 ± 0.006; p < 0.001; Fig. 3A, B). " |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Two-photon microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2981 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |