| Annotated protein: | Prohibitin-2 (B-cell receptor-associated protein BAP37) (BAP-37). Gene symbol: PHB2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q5XIH7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PHB2 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic active zone (GO:0048786) |
| Synapse type(s): | brain, glutamatergic brain, GABAergic |
| Annotated paper: | Boyken J, et al. "Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses" Neuron. 2013 Apr 24;78(2):285-97 PMID:23622064 |
| Figure(s): | Suppl. Tables S1, S5 (mmc2.xlsx, mmc4.xlsx) |
| Annotation description: | Prohibitin-2 (as well as Prohibition) copurifies with protein fractions highly enriched in docked synaptic vesicles. It is 5 - 9 fold enriched in docked SV vs. free SV. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Mass-spectrometry Biochemical fractionation (generic) |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| SynGO annotation ID: | 298 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |