| Annotated protein: | LHFPL tetraspan subfamily member 4 protein (GABAA receptor regulatory Lhfpl4) (Lipoma HMGIC fusion partner-like 4 protein). Gene symbol: LHFPL4. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q5U4E0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LHFPL4 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic specialization (GO:0099572) |
| Synapse type(s): | hippocampus, GABAergic |
| Annotated paper: | Yamasaki T, et al. "GARLH Family Proteins Stabilize GABA(A) Receptors at Synapses" Neuron. 2017 Mar 8;93(5):1138-1152.e6 PMID:28279354 |
| Figure(s): | Fig.1, 3 |
| Annotation description: | Fig.1: "Native GABAAR complexes contain Lhfpl4 and neuroligin-2" Fig.3: "The GABAAR γ2 subunit modulates expression of Lhfpl4 and neuroligin-2 in vivo" - "We found that LH4 and NL2 co-fractionated with γ2, α1 and β2/3 in glomeruli-enriched postsynaptic fractions in WT mice (Figure 3B). " |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) IP + WB/MSMS |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2976 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |