| Annotated protein: | Ras-related protein Rab-5A (EC 3.6.5.2) (Small GTP-binding protein rab5). Gene symbol: RAB5A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: M0RC99 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RAB5A |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic neurotransmitter receptor endocytosis (GO:0098884) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Brown TC, et al. "NMDA receptor-dependent activation of the small GTPase Rab5 drives the removal of synaptic AMPA receptors during hippocampal LTD" Neuron. 2005 Jan 6;45(1):81-94 PMID:15629704 |
| Figure(s): | Fig.2, 3, 4 |
| Annotation description: | Fig.2: " Rab5 Overexpression Selectively Depresses AMPA Receptor-Mediated Synaptic Transmission" Fig.3: "Rab5 Removes AMPARs Locally from the Spine Plasma Membrane" Fig.4: "Rab5(dn) Blocks and Rab5(wt) Mimics LTD in CA1 Neurons" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp Field recordings |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2975 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |