Annotated protein:SRC kinase signaling inhibitor 1 (SNAP-25-interacting protein) (SNIP) (p130Cas-associated protein) (p140Cap). Gene symbol: SRCIN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9QWI6
antibody wiki:
SynGO gene info:SynGO data @ SRCIN1
Ontology domain:Biological Process
SynGO term:regulation of synapse assembly (GO:0051963)
Synapse type(s):neocortex, glutamatergic
Annotated paper:Li MY, et al. "A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex" Neuron. 2017 Jun 21;94(6):1155-1172.e8 PMID:28641114
Figure(s):Fig.8
Annotation description:[Fig.4: "Presynaptic β-Catenin Is Sufficient to Promote Excitatory Synaptic Transmission and Spinogenesis"
Fig.6: "Enhanced β-Catenin Expression Induces Enlargement of Synaptophysin Puncta In Vivo"
Fig.7: "The Cadherin/Catenin Complex Regulates Release Probability"]

Fig.8: "The Cadherin/Catenin Complex Functions through p140Cap"

Note:
- Fig.5 "The Effect of β-Catenin Depends on Its Cell Adhesion, but Not Its Transcriptional Function"
- Conclusion: beta-catenin regulates organization of the presynapse via p140Cap.
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:RNAi / shRNA
Over-expression
Evidence tracking, Experiment Assay:Confocal
Whole-cell patch clamp
Annotator(s):Pim van Nierop (ORCID:0000-0003-0593-3443)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:2958
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology