| Annotated protein: | SRC kinase signaling inhibitor 1 (SNAP-25-interacting protein) (SNIP) (p130Cas-associated protein) (p140Cap). Gene symbol: SRCIN1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9QWI6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SRCIN1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of synapse assembly (GO:0051963) |
| Synapse type(s): | neocortex, glutamatergic |
| Annotated paper: | Li MY, et al. "A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex" Neuron. 2017 Jun 21;94(6):1155-1172.e8 PMID:28641114 |
| Figure(s): | Fig.8 |
| Annotation description: | [Fig.4: "Presynaptic β-Catenin Is Sufficient to Promote Excitatory Synaptic Transmission and Spinogenesis" Fig.6: "Enhanced β-Catenin Expression Induces Enlargement of Synaptophysin Puncta In Vivo" Fig.7: "The Cadherin/Catenin Complex Regulates Release Probability"] Fig.8: "The Cadherin/Catenin Complex Functions through p140Cap" Note: - Fig.5 "The Effect of β-Catenin Depends on Its Cell Adhesion, but Not Its Transcriptional Function" - Conclusion: beta-catenin regulates organization of the presynapse via p140Cap. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2958 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |