Annotated protein:Cadherin-10 (T2-cadherin). Gene symbol: CDH10. Taxonomy: Mus musculus (Mouse). Uniprot ID: P70408
antibody wiki:
SynGO gene info:SynGO data @ CDH10
Ontology domain:Cellular Component
SynGO term:synapse (GO:0045202)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Basu R, et al. "Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus" Neuron. 2017 Sep 27;96(1):160-176.e8 PMID:28957665
Figure(s):Fig.4
Annotation description:Fig.4: "Cadherin-9 Mediates Trans-cellular Adhesion via Cadherins-6 and -10"
- "We co-cultured neurons expressing Cdh9-smFPFLAG with neurons expressing Cdh6-smFPHA, Cdh10-smFPMYC, or both Cdh6-smFPHA and Cdh10-smFPMYC and immunostained for epitope tags and the synaptic markers vGLUT1 and PSD95. We observed co-localization of every pairwise combination of cadherins at synapses (Figures 4G-4I). "..."all three cadherins simultaneously co-localize at synaptic sites marked by juxtaposed vGLUT and PSD95 puncta (Figure 4J)."
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:Over-expression
Evidence tracking, Experiment Assay:Confocal
Annotator(s):Pim van Nierop (ORCID:0000-0003-0593-3443)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:2957
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology