Annotated protein:Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase). Gene symbol: EEF2K. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P70531
antibody wiki:
SynGO gene info:SynGO data @ EEF2K
Ontology domain:Biological Process
SynGO term:regulation of translation at postsynapse (GO:0140245)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Verpelli C, et al. "Synaptic activity controls dendritic spine morphology by modulating eEF2-dependent BDNF synthesis" J Neurosci. 2010 Apr 28;30(17):5830-42 PMID:20427644
Figure(s):Fig.2, 3, 4, 5, 6, 7, 8
Annotation description:Fig.2: "eEF2 phosphorylation by eEF2K plays a key role in remodeling spine morphology"

Fig.3: "eEF2 phosphorylation by eEF2K regulates synapse morphology"

Fig.4: "Activity regulates eEF2K-dependent spine morphogenesis"

Fig.5: "eEF2 phosphorylation by eEF2K regulates local protein synthesis"

Fig.6: "Neuronal activity modulates BDNF protein and transcripts in a biphasic manner, through the eEF2-eEF2K pathway"

Fig.7: "Activity modulates BDNF synthesis in dendrites"

Fig.8: "BDFN overexpression rescues spine phenotype due to eEF2K knock-down"
Evidence tracking, Biological System:Cultured neurons
Evidence tracking, Protein Targeting:RNAi / shRNA
Over-expression
Evidence tracking, Experiment Assay:Confocal
Western blot
Annotator(s):Pim van Nierop (ORCID:0000-0003-0593-3443)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:2946
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology