| Annotated protein: | Calnexin. Gene symbol: CANX. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P35565 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CANX |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic active zone membrane (GO:0099059) |
| Synapse type(s): | brain, glutamatergic |
| Annotated paper: | Boyken J, et al. "Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses" Neuron. 2013 Apr 24;78(2):285-97 PMID:23622064 |
| Figure(s): | Suppl. Table mmc2.xlsx |
| Annotation description: | Average enrichment of Calnexin in docked synaptic vesicles is 4.5 fold (Boyken et al. 2013). Note: To date Calnexin is considered mainly as a single-pass type 1 membrane protein of the ER membrane (Wiest et al. 1995). However, Calnexin has also been detected in postsynatic membranes (SynGO ID 295). Accordingly it may also appear in the presynaptic membrane. Alternatively the preparation may contain ER components. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Mass-spectrometry Biochemical fractionation (generic) |
| Annotator(s): | Daniela Dieterich (ORCID:0000-0002-9880-1214) Rainer Pielot (ORCID:0000-0002-9681-3318) Karl-Heinz Smalla (ORCID:0000-0002-0269-0311) Eckart Gundelfinger (ORCID:0000-0001-9377-7414) |
| Lab: | Leibniz Institute for Neurobiology (LIN), Institute of Pharmacology and Toxicology, Otto von Guericke University, Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany |
| Additional literature: | Calnexin is a single-pass type 1 membrane protein of the ER membrane. @ PMID:7628443 Calnexin is a type I endoplasmic reticulum integral membrane protein and responsible for the folding and quality control of newly-synthesized (glyco)proteins. To date its function has been assigned exclusively to ER-related compartments. @ PMID:26676362 |
| SynGO annotation ID: | 294 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |