| Annotated protein: | Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2). Gene symbol: TAOK2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9JLS3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ TAOK2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Yadav S, et al. "TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation" Neuron. 2017 Jan 18;93(2):379-393 PMID:28065648 |
| Figure(s): | Fig.1 |
| Annotation description: | Fig.1: "TAOK2 Localizes to Dendritic Spines and Its Kinase Activity Is Required for Spine Maturation" - "Our immunofluorescence analysis using an antibody that recognizes both isoforms of TAOK2 revealed that, in mature DIV18 hippocampal neurons, TAOK2 was present throughout the neuronal cytoplasm and also localized to the actin-rich dendritic spines and dendritic shaft (Figures 1A and S1A)." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2939 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |