| Annotated protein: | Calcyon neuron specific vesicular protein (Neuron-specific vesicular protein calcyon). Gene symbol: CALY. Taxonomy: Macaca Mulatta (Rhesus Macaque). Uniprot ID: F6VEL3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CALY |
| Ontology domain: | Cellular Component |
| SynGO term: | presynapse (GO:0098793) |
| Synapse type(s): | neocortex |
| Annotated paper: | Xiao J, et al. "Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis" J Biol Chem. 2006 Jun 2;281(22):15182-93 PMID:16595675 |
| Figure(s): | Fig.2 |
| Annotation description: | Fig.2: "Ultrastructural localization of calcyon in the macaque prefrontal cortex" - "vesicular intracellular organelles indicative of the endocytic and/or recycling machinery (28, 29) were labeled in extrasynaptic and intracellular regions of spines (Fig. 2B), dendrites (Fig. 2D), and axon terminals (Fig. 2C).The association of calcyon immunoreactivity to the intracellular side of the plasma membrane (Fig. 2, B-D) and the absence of labeling of the multivesicular bodies (MVB; Fig. 2, B and D) and of the synaptic membrane specialization of axon terminals and dendrites (Fig. 2, B-D) further support the observation that calcyon specifically localizes to intracellular endocytic pathways within neurons of the primate prefrontal cortex. Collectively, the above EM data highlight the potential for calcyon to regulate clathrin-mediated vesicle trafficking in neurons at several points along the endocytic and late secretory pathways (30)." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | See Fig.2+3 for additional EM data @ PMID:18539394 |
| SynGO annotation ID: | 2918 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |