| Annotated protein: | PRKCA-binding protein (Protein interacting with C kinase 1) (Protein kinase C-alpha-binding protein). Gene symbol: PICK1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9EP80 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PICK1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic endocytic zone (GO:0098843) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Fiuza M, et al. "PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 alpha-appendage and dynamin" J Cell Biol. 2017 Oct 2;216(10):3323-3338 PMID:28855251 |
| Figure(s): | Fig.1 |
| Annotation description: | Fig.1: "PICK1 colocalizes with clathrin in neuronal dendrites" - "GFP-PICK1 and dsRed-clathrin showed a colocalizing clustered distribution in dendrites (Fig. 1 A), and PICK1-clathrin clusters were closely associated with the postsynaptic density (PSD) marker Homer. However, a subset of PSDs was not associated with PICK1-clathrin clusters, consistent with previous studies of the distribution of EZs (Blanpied et al., 2002; also see Fig. S2 B). " |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Super resolution Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2916 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |