| Annotated protein: | Outer mitochondrial transmembrane helix translocase (EC 7.4.2.-) (ATPase family AAA domain-containing protein 1) (Thorase). Gene symbol: ATAD1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9D5T0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ATAD1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic neurotransmitter receptor endocytosis (GO:0099149) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Zhang J, et al. "The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior" Cell. 2011 Apr 15;145(2):284-99 PMID:21496646 |
| Figure(s): | Fig.2, 3, 4, 6 |
| Annotation description: | Fig.2: "Knockout of Thorase Increases AMPAR Surface Expression and AMPAR Currents" Fig.3: "Deficits in Homeostatic Synaptic Scaling and Endocytosis of AMPARs in Thorase KO neurons" Fig.4: "NMDA-induced AMPAR Internalization is Reduced in an ATPase-Dependent Manner in Thorase KO Neurons" Fig.6: "Thorase Deficiency Enhances AMPAR Currents and LTP and Impairs LTD Without Affecting Basal Synaptic Transmission at CA1 Hippocampal Synapses" Discussion: "In contrast, Thorase acts at GluR2-GRIP1 complexes to control the endocytosis and removal of AMPARs from the postsynaptic membrane. The identification of Thorase as a major regulator of AMPAR trafficking offers new opportunities to enhance the understanding and to identify additional regulators of AMPAR turnover." |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal Optical physiology |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2914 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |