| Annotated protein: | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8). Gene symbol: HSPA8. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P63018 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HSPA8 |
| Ontology domain: | Biological Process |
| SynGO term: | maintenance of postsynaptic specialization structure (GO:0098880) |
| Synapse type(s): | spinal cord, glycinergic |
| Annotated paper: | Machado P, et al. "Heat shock cognate protein 70 regulates gephyrin clustering" J Neurosci. 2011 Jan 5;31(1):3-14 PMID:21209184 |
| Figure(s): | Fig.6, 7 |
| Annotation description: | Fig.6: "Overexpression of Hsc70 decreases gephyrin clustering at synapses" - "We found that overexpressed VeHsc70 significantly decreased the intensity of gephyrin clusters compared with control neurons transfected with EGFP " Fig.7: "Hsc70 inhibition induces gephyrin clustering at synapses" - "CA treatment increased the fluorescence intensity of gephyrin clusters by 27 ± 5% compared with that measured in parallel control experiments" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2912 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |