| Annotated protein: | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8). Gene symbol: HSPA8. Taxonomy: Mus musculus (Mouse). Uniprot ID: P63017 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HSPA8 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic specialization membrane (GO:0099634) |
| Synapse type(s): | spinal cord, glutamatergic spinal cord, glycinergic |
| Annotated paper: | Machado P, et al. "Heat shock cognate protein 70 regulates gephyrin clustering" J Neurosci. 2011 Jan 5;31(1):3-14 PMID:21209184 |
| Figure(s): | Fig.2 |
| Annotation description: | Fig.2: "Gephyrin and Hsc70 colocalize at inhibitory synapses of spinal cord neurons from homozygous gephyrin-mRFP knock-in mice" - "Hsc70-IR was detected at synapses which could be either symmetric with flat vesicles (Fig. 2A4,5) or asymmetric with round vesicles (Fig. 2A6), likely corresponding to inhibitory and excitatory connections (Peters and Palay, 1996). More precisely, 14% of all synapses (n = 99) were labeled and, among the inhibitory ones (n = 71), 17% contained Hsc70-IR." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2911 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |