| Annotated protein: | Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1). Gene symbol: SYNJ1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8CHC4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SYNJ1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic neurotransmitter receptor endocytosis (GO:0099149) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Gong LW, et al. "Regulation of postsynaptic AMPA responses by synaptojanin 1" Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17561-6 PMID:18987319 |
| Figure(s): | Fig.1, 3, 4, 5 |
| Annotation description: | Fig.1: "Increased AMPA mEPSC amplitudes in hippocampal neuron from SJ1-KO mice" Fig.3: "Both SJ1-145 and SJ1-170 revert the increase in mEPSC amplitude observed in SJ1-KO neurons" Fig.4: "The phosphatase activity of SJ1 is necessary to restore normal mEPSC amplitude in SJ1-KO mice" Fig.5: "Internalization of AMPA receptors following the application of NMDA is impaired in SJ1-KO neurons" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp Optical physiology |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2910 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |