| Annotated protein: | Outer mitochondrial transmembrane helix translocase (EC 7.4.2.-) (ATPase family AAA domain-containing protein 1) (Thorase). Gene symbol: ATAD1. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9D5T0 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ATAD1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Zhang J, et al. "The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior" Cell. 2011 Apr 15;145(2):284-99 PMID:21496646 |
| Figure(s): | Fig.1 |
| Annotation description: | Fig.1: "The AAA+ ATPase, Thorase is a Cytosolic and Postsynaptic Protein that Regulates AMPAR Surface Expression" - "Thorase co-segregates with the postsynaptic proteins PSD95, GRIP1, GluR1, and GluR2 in the LP1 fraction (Figure 1D)." - "By confocal microscopy, Thorase is juxtaposed to the presynaptic marker synapsin 1 but colocalizes with the postsynaptic marker PSD95 (Figure 1E and 1F) GluR1 and GluR2 (Figure 1G and 1H). Co-immunostaining of Thorase and the axon specific marker SMI312 shows that Thorase is not expressed in axons (Figure S1K)." |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2909 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |