| Annotated protein: | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1-gamma) (PtdIns(4)P-5-kinase 1 gamma) (EC 2.7.1.68) (Phosphatidylinositol 4-phosphate 5-kinase type I gamma) (PIP5KIgamma). Gene symbol: PIP5K1C. Taxonomy: Mus musculus (Mouse). Uniprot ID: O70161 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PIP5K1C |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic neurotransmitter receptor endocytosis (GO:0099149) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Unoki T, et al. "NMDA receptor-mediated PIP5K activation to produce PI(4,5)P(2) is essential for AMPA receptor endocytosis during LTD" Neuron. 2012 Jan 12;73(1):135-48 PMID:22243752 |
| Figure(s): | Fig.4, 5, 6, 7 |
| Annotation description: | Fig.4: "Interaction of PIP5Kγ661 with AP-2 Is Essential for the NMDA-Induced AMPA Receptor Endocytosis" Fig.5: "PIP5Kγ661 Activity Is Required for the NMDA-Induced AMPA Receptor Endocytosis" Fig.6: "Suppression of NMDA-Induced AMPA Receptor Endocytosis by Knockdown of PIP5Kγ661" Fig.7: "Suppression of Hippocampal CA1-LTD by Inhibiting the Interaction of PIP5Kγ661 with AP-2 and by Expression of Kinase-Dead PIP5Kγ661 Mutant" |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp Western blot Biochemical fractionation (generic) |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | see also this paper. @ PMID:25355904 |
| SynGO annotation ID: | 2905 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |