| Annotated protein: | Activity-regulated cytoskeleton-associated protein (Activity-regulated gene 3.1 protein) (ARC/ARG3.1) (Arg3.1). Gene symbol: ARC. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q63053 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ARC |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic endosome (GO:0098845) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Chowdhury S, et al. "Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking" Neuron. 2006 Nov 9;52(3):445-59 PMID:17088211 |
| Figure(s): | Fig.5 |
| Annotation description: | Fig.5: "Arc and Endophilin Associate with Endosomes in Neurons" - "When co-expressed, Arc and endophilin 3 co-localized in puncta along the length of dendrites (Figure 5A). Thus, Arc redistributes to endophilin puncta in neurons. In addition, internalized GluR1 co-localized with endophilin 3 puncta (Figure 5B), suggesting that these puncta are receptor trafficking vesicles. Arc-endophilin vesicles also co-localized with endocytosed transferrin (Figure 5C), further suggesting that these are trafficking endosomes." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2902 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |