| Annotated protein: | Endophilin-A1 (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2) (SH3p4). Gene symbol: SH3GL2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O35179 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SH3GL2 |
| Ontology domain: | Cellular Component |
| SynGO term: | synaptic vesicle membrane (GO:0030672) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Chowdhury S, et al. "Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking" Neuron. 2006 Nov 9;52(3):445-59 PMID:17088211 |
| Figure(s): | Fig.2 |
| Annotation description: | Fig.2: "Endophilin 2, 3 and Arc Localize to Post-synaptic Sites with GluR1 in Hippocampal Neurons" - " Consistent with previous reports (Gad et al., 2000; Ringstad et al., 1999), endophilin 1 immunogold EM shows prominent localization to presynaptic vesicles (Figure 2A)." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2898 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |