Annotated protein:Endophilin-A2 (Endophilin-2) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) (SH3p8). Gene symbol: SH3GL1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O35964
antibody wiki:
SynGO gene info:SynGO data @ SH3GL1
Ontology domain:Cellular Component
SynGO term:presynapse (GO:0098793)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Chowdhury S, et al. "Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking" Neuron. 2006 Nov 9;52(3):445-59 PMID:17088211
Figure(s):Fig.2
Annotation description:Fig.2: "Endophilin 2, 3 and Arc Localize to Post-synaptic Sites with GluR1 in Hippocampal Neurons"
- "By contrast, endophilin 2 gold particles were enriched in both the pre- and postsynaptic compartments, and were prominent over the PSD and in the lateral margins of dendritic spines."
- " Vesicular structures containing endophilin 2 and 3 gold particles were present in both the spine and along microtubules in dendrites"
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Annotator(s):Pim van Nierop (ORCID:0000-0003-0593-3443)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:2897
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology