| Annotated protein: | Endophilin-A2 (Endophilin-2) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1) (SH3p8). Gene symbol: SH3GL1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: O35964 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SH3GL1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density, intracellular component (GO:0099092) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Chowdhury S, et al. "Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking" Neuron. 2006 Nov 9;52(3):445-59 PMID:17088211 |
| Figure(s): | Fig.2 |
| Annotation description: | Fig.2: "Endophilin 2, 3 and Arc Localize to Post-synaptic Sites with GluR1 in Hippocampal Neurons" - "By contrast, endophilin 2 gold particles were enriched in both the pre- and postsynaptic compartments, and were prominent over the PSD and in the lateral margins of dendritic spines." - " Vesicular structures containing endophilin 2 and 3 gold particles were present in both the spine and along microtubules in dendrites" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2896 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |