| Annotated protein: | Protein scribble homolog (Scribble) (Protein LAP4). Gene symbol: SCRIB. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q80U72 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SCRIB |
| Ontology domain: | Biological Process |
| SynGO term: | synaptic vesicle endocytosis (GO:0048488) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Sun Y, et al. "Scribble interacts with beta-catenin to localize synaptic vesicles to synapses" Mol Biol Cell. 2009 Jul;20(14):3390-400 PMID:19458197 |
| Figure(s): | Fig 5 |
| Annotation description: | The authors show that RNAi induced knockdown of Scribble results in decreased uptake of FM 4-64 at Syn-GFP positive puncta after high potassium stimulation (complete unloading of FM4-64 was observed after restimulation). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Tony Cijsouw (ORCID:0000-0003-0912-1514) Thomas Biederer (ORCID:0000-0002-3670-7863) |
| Lab: | Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA |
| SynGO annotation ID: | 2894 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |