| Annotated protein: | Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin). Gene symbol: DNM3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q08877 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DNM3 |
| Ontology domain: | Biological Process |
| SynGO term: | structural constituent of postsynapse (GO:0099186) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Lu J, et al. "Postsynaptic positioning of endocytic zones and AMPA receptor cycling by physical coupling of dynamin-3 to Homer" Neuron. 2007 Sep 20;55(6):874-89 PMID:17880892 |
| Figure(s): | Fig.2, 3 |
| Annotation description: | [Fig.2: "Dynamin-3 Concentrates in Dendritic Spines and Correlates with the Presence of an Endocytic Zone"] [Fig.3: "Dynamin-3 Localizes to Spine Membrane Domains Lateral to the PSD"] Fig.4: "A Dyn3-Homer-Shank Protein Complex Couples the EZ and the PSD" Fig.5: "Oligomerization of Dynamin-3 is Required to Link the Endocytic Machinery to the PSD" Fig.6: "Endogenous Dynamin-3 is Required for Postsynaptic Positioning of the Endocytic Zone" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2881 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |