| Annotated protein: | G protein-activated inward rectifier potassium channel 2 (GIRK-2) (Inward rectifier K(+) channel Kir3.2) (Potassium channel, inwardly rectifying subfamily J member 6). Gene symbol: KCNJ6. Taxonomy: Mus musculus (Mouse). Uniprot ID: P48542 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KCNJ6 |
| Ontology domain: | Biological Process |
| SynGO term: | voltage-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099508) |
| Annotated paper: | Jelacic TM, et al. "Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3" J Biol Chem. 2000 Nov 17;275(46):36211-6 PMID:10956667 |
| Figure(s): | Fig. 1 |
| Annotation description: | p.36213: FIG. 1. Inwardly rectifying channel currents are seen when GIRK2 and GIRK3 are co-expressed in CHO-K1 cells. CHO-K1 cells expressing GIRK2 and GIRK3 were analyzed by patch clamp in the inside-out configuration in symmetrical 140 mM K rule: NAS_MFCC-BP rationale: Protein has voltage-gated ion channel activity and is localized in teh presynaptic membrane (show with high-resolution technique). The inference to term 'voltage-gated ion channel activity involved in regulation of presynaptic membrane potential (GO:0099508)' is trivial and non-controversial. Pinf_CC: [P48542] SyNGO ID 285 (PMID:19558451, EM) |
| Evidence tracking, Biological System: | Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Non-tracable Author Statement (NAS): | This annotation required some inference over additional information/literature, and is not solely based on observations made in the annotated paper by its original authors. |
| Annotator(s): | Niels Cornelisse (ORCID:0000-0001-9425-2935) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 288 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |