| Annotated protein: | Dynamin-1 (EC 3.6.5.5). Gene symbol: DNM1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P39053 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DNM1 |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Fa M, et al. "Dynamin 1 is required for memory formation" PLoS One. 2014 Mar 18;9(3):e91954 PMID:24643165 |
| Figure(s): | Fig.6 |
| Annotation description: | Fig.6: "Selective dynamin 1 inhibition through siRNA impairs both synaptic plasticity and associative memory" - "Next, we infused Penetratin1-conjugated dynamin 1-siRNA (80 nM in a final volume of 1.5 μl over 1 minute, bilateral intrahippocampal infusions twice a day for 3 days prior to electrophysiology or behavior). We found a reduction in both contextual fear memory and LTP (Fig. 6B-D)." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2879 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |