Annotated protein:Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin). Gene symbol: DNM3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q08877
antibody wiki:
SynGO gene info:SynGO data @ DNM3
Ontology domain:Cellular Component
SynGO term:postsynaptic endocytic zone membrane (GO:0098844)
Synapse type(s):hippocampus, glutamatergic
Annotated paper:Lu J, et al. "Postsynaptic positioning of endocytic zones and AMPA receptor cycling by physical coupling of dynamin-3 to Homer" Neuron. 2007 Sep 20;55(6):874-89 PMID:17880892
Figure(s):Fig.2, 3
Annotation description:Fig.2: "Dynamin-3 Concentrates in Dendritic Spines and Correlates with the Presence of an Endocytic Zone"
Fig.3: "Dynamin-3 Localizes to Spine Membrane Domains Lateral to the PSD"
Evidence tracking, Biological System:Intact tissue
Cultured neurons
Evidence tracking, Protein Targeting:Over-expression
Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Confocal
Annotator(s):Pim van Nierop (ORCID:0000-0003-0593-3443)
Guus Smit (ORCID:0000-0002-2286-1587)
Matthijs Verhage (ORCID:0000-0002-2514-0216)
Lab:Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands
SynGO annotation ID:2877
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology