| Annotated protein: | Neuron-specific vesicular protein calcyon. Gene symbol: CALY. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9DCA7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CALY |
| Ontology domain: | Biological Process |
| SynGO term: | postsynaptic neurotransmitter receptor endocytosis (GO:0098884) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Davidson HT, et al. "Calcyon is necessary for activity-dependent AMPA receptor internalization and LTD in CA1 neurons of hippocampus" Eur J Neurosci. 2009 Jan;29(1):42-54 PMID:19120439 |
| Figure(s): | Fig.1, 2, 4, 5 |
| Annotation description: | Fig.1: "AMPA and NMDA induced AMPA receptor internalization is impaired in Calcyon knockout hippocampal neurons" Fig.2: "Knockout of calcyon inhibits NMDA-induced AMPA receptor internalization" Fig.4: "Chemical LTD in primary hippocampal cultures is calcyon dependent" Fig.5: "LTD in acute hippocampal slices is calcyon dependent" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp Western blot |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2873 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |