| Annotated protein: | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8). Gene symbol: HSPA8. Taxonomy: Mus musculus (Mouse). Uniprot ID: P63017 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ HSPA8 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynapse organization (GO:0099175) |
| Synapse type(s): | olfactory cortex, glutamatergic |
| Annotated paper: | Yagi H, et al. "Subcellular distribution of non-muscle myosin IIb is controlled by FILIP through Hsc70" PLoS One. 2017 Feb 24;12(2):e0172257 PMID:28234934 |
| Figure(s): | Fig.5 |
| Annotation description: | Fig.5: "The regulation of spine length by FILIP in primary neurons requires Hsc70" - "We did not observe an effect of VER-155008 on control neurons that did not express FILIP. However, VER-155008 treatment of FILIP-expressing hippocampal neurons led to significantly shorter spines than vehicle treatment of FILIP-expressing hippocampal neurons." Note: VER-155008 is a Hsc70-inhibitor. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2867 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |